This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

R. ROY FORSEY, M.D., F.R.C.P.(C); A. W. ANHALT, M.D.

AMA Arch Derm. 1956;74(4):352-354.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Much concentrated effort in research has been made in the past decade as to the etiology, pathology, and treatment of localized pretibial myxedema. Progress in the understanding of this condition, except that of therapy, has been encouraging. The association of exophthalmos and localized myxedema has been noted by many authors,^* and there would seem to be a common etiology.

The present concept is that this disease is not due to thyroid dysfunction but rather due to a disturbance of the pituitary-thyroid relationship. In hyperthyroidism, the thyroid-stimulating hormone of the anterior pituitary (TSH) is increased, and after thyroidectomy the TSH factor is no longer inactivated by thyroxin or some unknown factor of the thyroid. This factor of the anterior pituitary then continues, producing exophthalmos and/or pretibial myxedema. Lately a hormone has been isolated from the anterior pituitary gland which will cause exophthalmos.

General therapy has consisted of . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Dermatology, Montreal General Hospital.

Footnotes
Submitted for publication Dec. 21, 1955.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?