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Comparative Effectiveness in Dermatological Therapy

C. CONRAD SMITH, M.D.

AMA Arch Derm. 1956;74(4):414-415.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Topically applied hydrocortisone has been found to be effective in a variety of skin diseases.^* More recently the topical application of fluorohydrocortisone was found to be at least as effective as hydrocortisone, but requiring only one-tenth the concentration.

One of the most recently discovered and investigated steroids is prednisolone. Prednisolone differs from hydrocortisone in that it possesses an additional double bond in the A ring of the steroid structure at the 1,2 position. Systemically administered prednisolone¹⁰ requires only one-third the dose of hydrocortisone for the same therapeutic response. When given orally prednisolone has the additional advantage over hydrocortisone in that sodium restriction and potassium supplementation are unnecessary.

This report summarizes the results of topical application of prednisolone ointment in selected skin diseases, especially those responsive to hydrocortisone ointment. An attempt is made to compare the results of prednisolone ointment in various skin . . . [Full Text PDF of this Article]

Author Affiliations
Augusta, Ga.

Footnotes
Submitted for publication Aug. 19, 1955.

The prednisolone and hydrocortisone ointments were supplied by Chas. Pfizer & Company and The Upjohn Company.

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