This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of a Case in a Seven-Year-Old Girl

THOMAS BUTTERWORTH, M.D.

AMA Arch Derm. 1956;74(5):457-458.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Von Recklinghausen's disease usually runs a benign course, punctuated frequently by exacerbations produced by puberty, pregnancy, menopause, trauma, and infection. In some cases the tumors become stationary, but, on the other hand, sarcomatous change may take place in from 6.6% to 16% of patients, according to various authors. Most of the reported cases of malignancy have occurred in the third, fourth, and fifth decades of life and have had an approximately equal sex distribution. No definite relationship seems to exist between the occurrence of sarcoma and the number of cutaneous lesions. The malignant changes have a predilection for the deep nerves of the extremities and face, but cases of neurofibrosarcoma have been reported as originating in the mediastinum, retroperitoneal space, and along the gastrointestinal tract. In a very few patients, simultaneous malignant transformation has occurred in several tumors.

Clinically, the neurofibrosarcomas arising in . . . [Full Text PDF of this Article]

Author Affiliations
Reading, Pa.

From the Pennhurst State School, Spring City, Pa., Thomas Butterworth, M.D., consultant in dermatology.

Footnotes
Submitted for publication Feb. 10, 1956.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?