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Complications of Hydralazine (Apresoline) Therapy for Hypertension

J. GORDON ERICKSON, M.D.; EDGAR A. HINES, JR., M.D.; GERTRUDE L. PEASE, M.D.; LOUIS A. BRUNSTING, M.D.

AMA Arch Derm. 1956;74(6):640-647.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During the past two years hydralazine hydrochloride (1-hydrazinophthalazine hydrochloride; Apresoline) has been used extensively in the treatment of hypertension. Its reputed ability to reduce arterial pressure through its central action¹ and to increase renal circulation² accounts in part for its usefulness as an antihypertensive agent.

A syndrome, however, appeared among patients using hydralazine, with symptoms which ranged from mild migratory arthralgic pains to symptoms resembling early acute rheumatoid arthritis or acute systemic lupus erythematosus, according to Dustan and his group^* and to Perry and Schroeder. Other isolated cases reported in the recent literature include those of Manter,⁷ Feder,⁸ Reinhardt and Waldron,⁹ and Shackman and associates.¹⁰ Kaufman¹¹ reported a case of pancytopenia due to hydralazine.

This report is an analysis of the late reactions in a group of patients treated with oral administrations of hydralazine . . . [Full Text PDF of this Article]

Author Affiliations
Van Nuys, Calif.; Rochester, Minn.

Footnotes
Submitted for publication Jan. 19, 1956.

Fellow in Dermatology, Mayo Foundation (Dr. Erickson); Section of Medicine (Dr. Hines), Section of Clinical Pathology (Dr. Pease), and Section of Dermatology (Dr. Brunsting), Mayo Clinic and Mayo Foundation. The Mayo Foundation is a part of the Graduate School of the University of Minnesota.

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