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ALFRED W. KOPF

AMA Arch Derm. 1957;75(1):1-37.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

I. Introduction

Alkaline phosphatase is an enzyme widely distributed in various tissues of the body. There are only few reports concerning alkaline phosphatase^* in skin disease, and the norms for healthy tissue have not been completely established.

It was the purpose of this work to perform adequately controlled investigations in order to elucidate the distribution of AP in normal human skin and in 68 dermatologic conditions.

A. The Physiologic Significance of Alkaline Phosphatase

Although AP is found in all organs of the body, its role in the physiology of organs, other than bone, is more or less obscure.

The physiologic role of AP is best understood in the processes of calcification and ossification.^{47,50,59,83,88,100,101,119,140} Alkaline phosphatase is also found histochemically in certain sites of fibroplasia,^{6,11,16,30,36,55,70,78, 121,142,166,182} inflammatory reaction,^83,162, glandular secretion,^{31,37,39,40,48,49,122,147,165, 166} absorption and resorption by epithelium, histodifferentiation,^{92,93,135,137} and transmembranous solute passage,138 but . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Dermatology and Syphilology of the New York University Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman) and the Skin and Cancer Unit, University Hospital, New York University-Bellevue Medical Center.

Footnotes
Received for publication July 31, 1956.

Prize-winning essay read before the Seventy-Sixth Annual Meeting of the American Dermatological Association, Inc., Santa Barbara, Calif., June 18, 1956.

Dr. Arthur Bernard Hyman suggested this study. He has guided me in this work from its conception to its completion, in the reading and interpretation of some 1600 slides, and in the preparation of the manuscript.

This work represents a condensation of the thesis submitted to the faculty of the New York University Post-Graduate Medical School in partial fulfillment of the requirements for the degree of Master of Science in Dermatology and Syphilology.

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