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Eosinophilic Granuloma of Skin and Mucous MembraneAssociation with Diabetes Insipidus
ROBERT B. KIERLAND, M.D.;
JOHN G. EPSTEIN, M.D.;
WALTER E. WEBER, M.D.
AMA Arch Derm. 1957;75(1):45-54.
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The dermatologic disturbances associated with the group of conditions which includes eosinophilic granuloma,* Hand-Schüller-Christian  and Letterer-Siwe  disease have been reviewed thoroughly elsewhere.
The cutaneous findings in acute Letterer-Siwe disease are generally of a petechial, ecchymotic, or purpuric nature. Eruptions resembling seborrheic dermatitis have been noted, and even a necrotic, ulcerating angina of the oral mucosa has been reported in one case. The histologic picture is essentially the same regardless of the system involved, that is, skin, viscera, or bone.
Approximately one-third of the patients with Hand-Schüller-Christian disease have cutaneous lesions. These consist of papulopustular eruptions, seborrheic and purpuric lesions, bronze discoloration, and occasionally lipoid infiltration about the eyes and xanthomas, especially of the disseminate variety.
Cutaneous alterations are rarely seen in association with eosinophilic granuloma of bone. However, granulomatous lesions with the same histologic structure as eosinophilic lesions of bone have been noted
. . . [Full Text PDF of this Article]
Author Affiliations
Santa Rosa, Calif.
Footnotes
Received for publication March 29, 1956.
Dr. Hamilton Montgomery aided in the interpretation of the histologic sections.
Section of Dermatology, Mayo Clinic and Mayo Foundation (Dr. Kierland); Fellows in Dermatology, Mayo Foundation (Drs. Epstein and Weber). The Mayo Foundation is a part of the Graduate School of the University of Minnesota.
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