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S. WILLIAM BECKER, M.S., M.D.; STANLEY H. MOUNCE, M.D.

AMA Arch Derm. 1957;75(3):333-344.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Of the two most important drugs used in the systemic therapy of tuberculosis, streptomycin has been reported to have caused dermatoses more frequently than nervous disorders, while administration of isonicotinic acid hydrazide (isoniazid) has been prone to result in more nervous disorders than dermatoses.

Three types of cutaneous reaction to streptomycin were reported by Combes and associates¹: (a) early polymorphous biotropic type of exanthem appearing before the 10th day, which responds to antihistaminics and does not require cessation of therapy; (b) exfoliative dermatitis after many weeks of treatment, necessitating its cessation, and (c) troublesome contact dermatitis of high incidence, especially in nurses continually in contact with the drug over long periods, necessitating either wearing of rubber gloves, frequent rotation of nurses, or removal from further contact. In the following year, Craps² listed the dermatoses resulting from streptomycin therapy: simple pruritus; erythema, more . . . [Full Text PDF of this Article]

Author Affiliations
Long Beach, Calif.

From the Section of Dermatology and Syphilology, Long Beach Veterans Administration Hospital.

Footnotes
Received for publication Aug. 10, 1956.

Read before the 76th Annual Meeting of the American Dermatological Association, Inc., Santa Barbara, Calif., June 21, 1956.

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