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Pathergic GranulomatosisReport of Two Cases Formerly Designated Wegener's Granulomatosis and Malignant Granuloma of the Face
THOMAS H. STERNBERG, M.D.;
JOHN REYNOLDS, M.D.;
ROBERT H. ZEILENGA, M.D.
AMA Arch Derm. 1957;75(3):368-379.
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An editorial in a recent issue of The American Journal of Medicine proposed the diagnosis of "pathergic granulomatosis" for a group of conditions characterized by necrotizing granulomata and angiitis and involving multiple tissues or single organs. The author, Robert Fienberg,1 considered Wegener's granulomatosis as an example of disseminated pathergic granulomatosis and suggested that idiopneumonic granulomatosis, pneumonitis of the cholesterol type, eosinophilic granuloma of the lung, and Cogan's syndrome are examples of the focal type.
The purpose of this article is to report two cases which we believe are instances of pathergic granulomatosis, one disseminated and the other focal. The disseminated case fulfills the clinical and pathologic criteria associated with Wegener's granulomatosis. The focal case was diagnosed as malignant granuloma of the face, but we believe it may be an additional example of a focal pathergic granulomatosis not mentioned by Fienberg.
This report also includes a
. . . [Full Text PDF of this Article]
Author Affiliations
Los Angeles
From the Division of Dermatology, Department of Medicine (Drs. Sternberg and Zeilenga) and the Department of Medicine (Dr. Reynolds), University of California Medical Center.
Footnotes
Received for publication Aug. 22, 1956.
Read before the 76th Annual Meeting of the American Dermatological Association, Inc., Santa Barbara, Calif., June 21, 1956.
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