SPECIAL ADDRESS
DR. JOHN A. KENNEY JR. Presiding
Mechanisms of Blister Formation 
The Treatment of Pemphigus with Acth
Dr. Richard B. Stoughton*
In a series of 12 cases of pemphigus vulgaris followed for as long as seven years, we have been able to control the disease primarily with the use of ACTH gel. There was one fatality due to coronary occlusion, but none of these patients died as a result of the lesions of pemphigus vulgaris.
The average maintenance dose of ACTH varied with each patient and had to be continually adjusted for each individual patient over the years. Almost all of the care these patients received was supervised on an outpatient basis. Most of the patients required daily injections, which were given by the patient, a relative, or a visiting nurse.
In the beginning, these patients were closely followed in regard to weight gain, electrolyte changes,
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