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Interference in Pityriasis Rubra Pilaris, Ichthyosis, and Psoriasis as Shown by Fluorescent Microscopy

THEODORE CORNBLEET, M.D., Ph.D.; RUVEN GREENBERG, Ph.D.

AMA Arch Derm. 1957;76(4):431-433.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recently, we demonstrated the conversion of carotene to vitamin A by the cells of sebaceous glands.¹ The carotene, in the original carrot oil, was prepared as a water-solubilized suspension. It was injected intradermally. Upon histologic examination by fluorescent microscopy, the injected carotene was identified within the dermis by its bright yellow-gold color; the derived vitamin A was identified by its characteristic green fading fluorescence.²

A part of the injected carotene was concentrated exclusively by the cells of the sebaceous glands; it was not concentrated by any other cells of the skin or its appendages. Subsequently, within minutes, detectable concentrations of vitamin A were visualized within the same sebaceous cells and especially within the sebum at the neck of the gland, in the hair follicle, and upon the skin surface.

Normally, neither carotene nor vitamin A are detectable in these sites,^2-4 probably be . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Departments of Dermatology and Physiology, University of Illinois College of Medicine and the Cook County Hospital.

Footnotes
Submitted for publication March 29, 1957.

This research supported in part by grants from the Committee on Research, American Medical Association, and the University of Illinois Graduate Research Board.

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