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WILLIAM L. EPSTEIN, M.D.; ALBERT M. KLIGMAN, M.D., Ph.D.

AMA Arch Derm. 1957;76(4):437-445.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous paper,¹ we proposed that the different varieties of cutaneous epithelial tumors do not originate from fixed loci, but may spring from any portion of the cutaneous epithelial system, i. e., the epidermis and its derivative adnexa. Basal-cell carcinomas, for example, may arise from the epidermis, the eccrine and apocrine systems, or the pilosebaceous units, though doubtlessly some sites are preferred. Furthermore, we concluded that a tumor, whatever its origin, could differentiate along different and multiple lines, so that its source could not be known positively from its final form; that is to say, it cannot be assumed that a syringoma or trichoepithelioma arises respectively from sweat ducts or hair follicles. The pluripotentiality of the cells making up the cutaneous epithelial system is the biological foundation on which our thesis of tumor formation rests. The capacity of such cells to transform into . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Department of Dermatology (Donald M. Pillsbury, M.D., Professor), University of Pennsylvania School of Medicine.

Footnotes
Submitted for publication Jan. 24, 1957.

This work was supported by the Research and Development Division, Office of the Surgeon General, Department of the Army, Contract No. DA-49-007-MD-154.

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