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CHARLES GEORGE STEFFEN, M.D.; RICHARD MIHAN, M.D.; MURRAY ZIMMERMAN, M.D.

AMA Arch Derm. 1957;76(4):463-465.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction and Review of Literature

It has been established that the antihistamines are effective local anesthetic agents, and that they are valuable as a substitute drug for patients who are either allergic to procaine or who obtain unsatisfactory anesthesia from procaine.^1-4 However, their clinical use has been limited because of the reported local side-effects and toxic reactions following intracutaneous injection. It is the purpose of this study to investigate further the toxic effects of one of the antihistaminic drugs, tripelennamine (Pyribenzamine).

Leavitt and Code⁵ studied the local irritant effects of the antihistamine diphenhydramine (Benadryl). They stated that the results of tests performed by the injection of diphenhydramine intracutaneously indicated that the drug had definite irritant properties when administered in concentrations greater than 1:500 (2 mg. per cubic centimeter). Injection caused burning pain, redness, and edema. Sloughing and ulceration . . . [Full Text PDF of this Article]

Author Affiliations
Covina, Calif.; Los Angeles; Whittier, Calif.

From the Department of Dermatology, University of Southern California, Maximilian E. Obermayer, Director; and the Section of Dermatology, Los Angeles County General Hospital, Maximilian E. Obermayer and Maxwell J. Wolff. Co-Chairmen.

Footnotes
Submitted for publication April 10, 1957.

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