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JOHN H. COOPER, M.B., Ch.B.

AMA Arch Derm. 1958;77(1):18-22.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Reports by electron miscroscopists^1,2 of the presence of a discrete homogeneous basement or basal membrane in human skin are difficult to reconcile with the orthodox histological view that there is no true subepidermal basement membrane and that dermal-epidermal adhesion is effected by an interdigitation and interlocking between the foot processes of the basal epidermal cells and the subepidermal "reticular fibers." This orthodox view has recently been restated and upheld both by Allen³ and Winkelmann.⁴

The discrepancy can be attributed largely to the reliance many histologists place on silver-impregnation methods as a means of staining basement membranes, for the argyrophil material at the dermal-epidermal junction is of discontinuous nonmembranous appearance and bears no morphological resemblance to the apparent membranes which silver impregnation can reveal around renal tubules and many other glandular structures. It is one thesis of this paper that these argyrophilic membranous . . . [Full Text PDF of this Article]

Author Affiliations
St. John's, Nfld., Canada

Footnotes
Submitted for publication June 4, 1957.

Assistant Pathologist, General Hospital and Public Health Laboratories.

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