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Clinical Features and Differential Diagnosis

GEORGE W. HAMBRICK, Jr., M.D.

AMA Arch Derm. 1958;77(1):23-33.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Dysproteinemic purpura is a more or less chronic condition characterized by purpura and by a serum protein pattern which is abnormal qualitatively, quantitatively, or both. Three types of this condition have been recognized.

In 1943 "purpura hyperglobulinemica" was described by Waldenström¹; in his patients purpura of the legs of a chronic, recurrent type was accompanied by an increase in serum -globulin and elevated sedimentation rate without definite, recognizable systemic disease. Subsequently, macroglobulinemia of Waldenström^2,3 in 1944 and cryoglobulinemia of Lerner and Watson⁴ in 1947 were recognized as distinct dysproteinemic syndromes with hyperglobulinemia. Lerner and Watson stated that purpura cryoglobulinemica could be considered a special type of purpura hyperglobulinemica of Waldenström. In this paper "dysproteinemic purpura of the hypergammaglobulinemic type" will be used to designate the original syndrome of "purpura hyperglobulinemica of Waldenström."^*

Although a peculiar, hyperpigmented purpura of the legs is the . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Department of Dermatology (Donald M. Pillsbury, M.D., Director), School of Medicine, University of Pennsylvania.

Footnotes
Received for publication July 1, 1957.

This study was supported by Army Grant DA 49-007-MD-154.

Read before the Section on Dermatology at the 106th Annual Meeting of the American Medical Association, New York, June 5, 1957.

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