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II. Action of Epinephrine and Phentolamine (Regitine); Action of Acetylcholine and Methacholine (Mecholyl), and the "Delayed Blanch"

WILLIAM B. REED, M.D.

AMA Arch Derm. 1958;77(2):181-186.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Part I of these studies on vascular reactions in chronically inflamed skin dealt with mechanical cutaneous stimulation and the inhibition of white dermographism.¹ This part will consider the action of epinephrine and phentolamine (Regitine), and the action of acetylcholine and methacholine (Mecholyl), together with a discussion of the "delayed blanch" phenomenon.

Action of Epinephrine and an Inhibitor, Phentolamine

The most powerful physiologic agents for constricting the blood vessels of the skin are epinephrine and arterenol (norepinephrine), both of which are elaborated by the adrenal medulla and at the ends of postganglionic sympathetic fibers. Arterenol probably is the major adrenergic mediator at the postganglionic neuroeffector junctions, whereas epinephrine is the predominant sympathomimetic amine released by the adrenal medulla. Epinephrine is thought to be formed by the methylation of arterenol, the methyl group coming from such methyl donors as methionine.²

Arterenol and epinephrine act directly on . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn.

Footnotes
Portion of the essay awarded fourth prize in the annual essay contest of the American Dermatological Association, Inc., in 1956.

Abridgment of portion of thesis submitted by Dr. Reed to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Dermatology.

Fellow in Dermatology, Mayo Foundation (Dr. Reed), and Section of Dermatology (Dr. Kierland), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

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