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DONALD S. SCHUSTER, M.D.; WALKER A. LEA, Jr., M.D.; WALTER D. BLOCK, Ph.D.; ARTHUR C. CURTIS, M.D.

AMA Arch Derm. 1958;77(6):713-714.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Free-moving-boundary electrophoresis^1,2 has facilitated the study of serum protein in both normal and disease states.³ In most disease states the electrophoretic pattern is nonspecific.⁴ However, characteristic changes do exist in hemophilia,⁵ lupus erythematosus,⁶ hypogammaglobulinemia, nephrosis, and multiple myeloma.³ In primary familial systemic amyloidosis free-moving-boundary electrophoresis has revealed the presence of a subclinical serum protein aberration.⁷

It seemed possible that free-moving-boundary electrophoresis might detect a subclinical abnormality in the uninvolved members of a family in which clinical psoriasis was present. Since genetic factors are present in this disease,^8,9 electrophoretic abnormalities were sought in such persons.

Methods

A family, consisting of a mother, five children, and one grandchild, was selected for this study (Figure). A fasting blood specimen was drawn from each subject. Free-moving-boundary electrophoresis was carried out in barbital (Veronal) buffer, at pH 8.6 and ionic strength 0.1µ, according to . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich.

From the Department of Dermatology and Syphilology, University of Michigan School of Medicine.

Footnotes
Submitted for publication Feb. 12, 1958.

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