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Necrobiosis Lipoidica DiabeticorumA Biochemical, Histochemical, and Electrophoretic Study
MARVIN F. ENGEL, M.D.;
WILLIAM J. HAMMACK, M.D.
AMA Arch Derm. 1958;78(1):73-81.
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Necrobiosis lipoidica diabeticorum is a chronic cutaneous disorder, occurring usually in females and found almost entirely on the anterior surface of the lower extremities. The lesions are characterized by single to multiple sharply demarcated, oval, firm, yellowish, shiny plaques with a violaceous border (Figs. 1 and 2).
The purpose of this paper is not to review the literature on necrobiosis lipoidica diabeticorum, as this has been done in the past by Hildebrand, Montgomery, and Rynearson1 and more recently by Hare,2 but rather to attempt to resolve the still unanswered question of its relationship to diabetes mellitus. Studies were done to determine the formative mechanism of the vascular lesions, to show possible reasons for the common occurrence of the lesion at the anterior tibial region, and to determine the reason for its predominance in females. To accomplish these objectives, a study was made of
. . . [Full Text PDF of this Article]
Author Affiliations
Birmingham, Ala.
Footnotes
Received for publication Jan. 24, 1958.
The University of Alabama Medical Center.
Resident in Dermatology, Department of Dermatology (Ray O. Noojin, M.D., Professor and Chairman), University of Alabama Medical Center, Birmingham (Dr. Marvin F. Engel), Instructor in Medicine, Department of Medicine, University of Alabama Medical Center, Birmingham (Dr. William J. Hammack).
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