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J. B. SHELMIRE, Jr., M.D.

AMA Arch Derm. 1958;78(2):191-195.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A previous study in this series¹ examined the relation between the vehicle and the relative rate of diffusion to the skin surface of an incorporated substance.

The present investigation concerns the effect of the vehicle on the percutaneous penetration of substances known to penetrate human skin.

The Vehicles

Vehicles were previously classified as (1) oil-in-water emulsion, (2) aqueous, (3) water-in-oil emulsion, (4) grease, and (5) nonvolatile water-miscible.

An example of each type was used in this study, with the exception of an aqueous vehicle. Rapid evaporation and subsequent concentration of incorporated substances make an aqueous vehicle unsuitable for this study. An anhydrous water-in-oil emulsion was included for the investigation of several specific points.

The oil-in-water emulsions were conpounded to meet the requirements thought necessary for a series of test vehicles. Two are included, since all of the drugs studied were not compatible with any one. The . . . [Full Text PDF of this Article]

Author Affiliations
Dallas, Texas

Footnotes
Submitted for publication Jan. 22, 1958.

Clinical Instructor in Dermatology, Southwestern Medical School of The University of Texas.

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