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Genetic Studies on Acanthosis Nigricans
HELEN OLLENDORFF CURTH, M.D.;
BERTHA M. ASCHNER, M.D.
AMA Arch Derm. 1959;79(1):55-66.
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In a previous paper by one of us (H. O. C.1) the separate character of benign and malignant acanthosis nigricans was stressed. Differences between the two types exist with regard to the age of the patient at the onset of the dermatosis, the course, and the activator of the disorder. It was also pointed out that there may be in the genetic background of the two types significant differences which could furnish additional evidence for the assumption that benign and malignant acanthosis nigricans are separate diseases. The result of our genetic studies has confirmed our early impression.
Since some controversy over the necessity of recognizing different types of acanthosis nigricans has arisen, we shall briefly define benign and malignant acanthosis nigricans before reporting our genetic data on these forms of the dermatosis. Pseudo acanthosis nigricans, a third variety, will also be described, and the reasons
. . . [Full Text PDF of this Article]
Author Affiliations
New York
From The Department of Dermatology, College of Physicians and Surgeons, Columbia University.
Footnotes
Submitted for publication April 17, 1958.
This investigation was supported by Research Grant C 1603 from the National Cancer Institute, National Institutes of Health, Public Health Service.
This paper was read in abbreviated form in the Symposium on Ichthyosiform Genodermatoses at the 11th International Congress of Dermatology, Stockholm, Sweden, Aug. 1, 1957, and in the Symposium on Hereditary Dermatoses of the American Academy of Dermatology and Syphilology, Chicago, Dec. 9, 1957.
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