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CLAYTON E. WHEELER, M.D.; CHARLES M. CANBY, M.S.

AMA Arch Derm. 1959;79(1):86-95.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Persons who suffer from recurrent herpes simplex infections have neutralizing or complement-fixing antibodies to herpes simplex virus in their sera, usually in high titer.^{4,6-9,11-16,18-20} The antibody level in the sera of these patients, according to available evidence,^6,9,11-16,19 does not fluctuate in response to the recurrent infection. (The anibody level is as high before the recurrence as it is during or after.) These observations suggest that a high level of specific antibody in the serum is incapable of eradicating the herpes virus even though it may limit its spread.

The influence of specific antibody upon the course of experimental herpes infections in tissue cultures has been studied by two groups of investigators. Andrewes³ showed that herpes simplex infections could develop in tissue cultures in the presence of specific antibody providing the virus was added one-half hour before the addition of the antibody. Black and . . . [Full Text PDF of this Article]

Author Affiliations
Charlottesville, Va.

From the Departments of Dermatology and Microbiology, University of Virginia Department of Medicine Associate Professor of Dermatology (Dr. Wheeler) and Research Assistant (Mr. Canby).

Footnotes
Submitted for publication July 14, 1958.

This work was supported by U. S. P. H. S. Grants E1439(C1) and E1439(C2).

Read before the 78th Annual Meeting of the American Dermatological Association, Inc., Sun Valley, Idaho, June 5, 1958.

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