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HARVEY BLANK, M.D.; FRANK J. ROTH, Jr., Ph.D.; William W. Bruce, M.D.; Marvin F. Engel, M.D.; J. Graham Smith, Jr., M.D.; Nardo Zaias, M.D.

AMA Arch Derm. 1959;79(3):259-266.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The systemic treatment of superficial fungus infections in man at last seems a near reality. Although the polyene antibiotics derived from streptomyces were a significant advance in antifungal chemotherapy against the yeast-like fungi, they failed to influence the common dermatomycoses.¹ Recent studies demonstrating the influence of serum factors in superficial fungous infections illustrated the importance of blood-borne substances in confining cutaneous invasion by dermatophytes.^2,15 Gentles' recent report of the successful oral treatment of Trichophyton and Microsporum infections in guinea pigs with griseofulvin, a product of several penicillia, was a great step forward.⁷ Subsequently, Lauder and O'Sullivan found it effective by mouth in calves with Trichophyton verrucosum infections.¹¹ Our paper is a preliminary report of observations on the effectiveness of oral griseofulvin therapy in man.

Griseofulvin is a colorless, neutral, thermostable antibiotic isolated from Penicillium griseofulvin by Oxford, Raistrick, and Simonet, . . . [Full Text PDF of this Article]

Author Affiliations
Miami, Fla.

From the Division of Dermatology, Department of Medicine, University of Miami School of Medicine, Miami, Fla., and the Veterans Administration Hospital, Coral Gables, Fla.

Footnotes
Submitted for publication Dec. 31, 1958.

Presented at the American Academy of Dermatology & Syphilology, Chicago, Dec. 6-11, 1958.

This study was supported in part by U. S. Army Contract No. DA-49-007-MD-731 and by grants from the Hazen-Brown Fund of Research Corporation and from the National Institutes of Health, PHS No. E-1546.

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