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Gamma-Globulin Therapy in Chronic Staphylococcic DermatosesA Comparison of Serum Gamma-Globulin Levels and Serum Antibacterial Activity
W. J. MORGINSON, M.D.;
DON C. WOOD, PH.D.;
LURRINE BURGESS, B.A.
AMA Arch Derm. 1959;79(3):305-310.
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Bruton1 reported that decreased serum  -globulin may accompany susceptibility to infection. It is, therefore, important to consider dysgammaglobulinemia, hypogammaglobulinemia, and agammaglobulinemia in patients presenting acute and chronic infectious dermatoses. -Globulin serum levels have been extensively documented for many dermatologic entities, generally representing the acute infectious and severe varieties. The chronic dermatoses, in which staphylococcic diathesis is an important feature, have received less attention.
The purpose of this study is to (1) determine whether the sera of patients with chronic staphylococcic dermatoses have a lowered antibacterial titer, (2) to determine whether the serum -globulin levels are reduced, and (3) to observe the response of these dermatoses to -globulin therapy.
Investigational Methods
Three general methods were used during this investigation.
A. Clinical Classification of Chronic Staphylococcic Dermatoses and Response to -Globulin Therapy.—The chronic staphylococcic dermatoses are divided into diagnostic groups for a more
. . . [Full Text PDF of this Article]
Author Affiliations
Salt Lake City
From the Division of Dermatology, Department of Medicine, and the Department of Pathology, University of Utah College of Medicine and the Veterans' Administration Hospital.
Footnotes
Submitted for publication Aug. 7, 1958.
Read before the Section on Dermatology at the 107th Annual Meeting of the American Medical Association, San Francisco, June 25, 1958.
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