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Association of Immediate and Delayed Types of Pollen Sensitivity

SHELDON G. COHEN, M.D.

AMA Arch Derm. 1959;79(3):328-333.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Evidence for the etiologic role of ragweed pollen in the production of seasonal dermatitis has been well documented.^1-4 Although possessing the common denominator of hypersensitivity, there are two distinct morphologic types of ragweed dermatitis, each dependent upon a different immunologic mechanism. One is typical atopic dermatitis associated with an immediate intracutaneous whealing response to the water-soluble pollen fraction, mediated through circulating serum reaginic antibody to ragweed. Here, the challenging exposure to wind-dispersed pollen grains occurs through the inhalant route. The second variety is allergic eczematous dermatitis of the contact type, mediated through a tissue-sensitizing factor and demonstrated by the delayed epidermal response to patch testing with the ether-acetone-soluble pollen fraction, "ragweed oil." This is further characterized by an inability to detect circulating serum antibody in the patient whose exposure to the oil-containing ragweed pollen, leaf, or stem is by direct cutaneous . . . [Full Text PDF of this Article]

Author Affiliations
Wilkes-Barre, Pa.

From the Department of Biology, Wilkes College; Associate Professor of Biological Research.

Footnotes
Submitted for publication July 17, 1958.

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