 |
|
Blood Histamine and Basophil-Eosinophil Counts in Skin Diseases
HERMAN J. SCHULTZ, M.D.;
CHARLES F. CODE, M.D.;
LOUIS A. BRUNSTING, M.D.
AMA Arch Derm. 1959;80(1):44-52.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Shortly after histamine was first synthesized by Windaus and Vogt, in 1907,1 its physiologic properties were described by Dale and Laidlaw,2 who at the same time called attention to the similarity between the symptoms produced by administration of histamine and those of anaphylaxis. Later, Lewis3 observed that when stimuli of different kinds were applied to the skin, all elicited a common type of response, which he termed the "triple response." Noting the similarity between that response and histamine-induced wheals, he postulated that the triple response must be due to the liberation by injured cells of a histamine-like substance, which he called "H-substance." Much investigation has ensued in attempts to substantiate histamine as the chemical mediator of anaphylaxis in animals and of allergy in man. Since many dermatologic conditions are partially or totally allergic in origin, estimates have been made of the metabolism of histamine
. . . [Full Text PDF of this Article]
Author Affiliations
Rochester, Minn.
Footnotes
Submitted for publication Oct. 16, 1958.
Abridgment of thesis submitted by Dr. Schultz to the faculty of the Graduate School of the University of Minnesota, in partial fulfillment of the requirements for the degree of Master of Science in Dermatology.
Fellow in Dermatology (Dr. Schultz), Section of Physiology (Dr. Code), and Section of Dermatology (Dr. Brunsting), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
