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A Clinical Trial

WILSON M. FRASER, M.D.; JOHN M. KNOX, M.D.

AMA Arch Derm. 1959;80(4):436-438.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A previously unknown Streptomyces species, isolated from a soil sample obtained at Tembladora, on the Orinoco River in South America, has been found to produce two amphoteric antifungal agents which have been named amphotericin A and amphotericin B.¹ Studies of their physical properties reveal slight differences between the infrared absorption spectra of the two materials. Crystalline amphotericin A exhibits the ultraviolet absorption curve of a conjugated tetraene similar to rimocidin or nystatin, while the absorption curve for amphotericin B is characteristic of a conjugated heptaene, and is similar to ascosin and trichomycin. These compounds also have different solubilities in various organic solvents. Although the chemical structure is not known, elementary analysis indicates that both compounds contain carbon, hydrogen, and nitrogen in similar proportion and do not contain halogen, sulfur, methoxyl, or acetyl groups.² Pharmacological studies reveal that the two compounds are very poorly absorbed . . . [Full Text PDF of this Article]

Author Affiliations
Houston, Texas

From the Department of Dermatology, Baylor University College of Medicine (Everett R. Seale, Chairman); Associate Professor of Dermatology (Dr. Knox).

Footnotes
Submitted for publication Feb. 27, 1959.

The amphotericin for this study was supplied by E. R. Squibb & Sons, New York.

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