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Experiences with the Treponema Pallidum Complement-Fixation (TPCF) and Reiter Protein Complement-Fixation (RPCF) Tests

GEORGE H. KOSTANT, M.D.; SIMEON E. LANDY, M.D.; JAMES N. MILLER, Ph.D.; LOUISE C. KELCEC, M.T.

AMA Arch Derm. 1959;80(4):439-441.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Previous studies employing treponemal antigens on spinal fluid have dealt for the most part with the Treponema pallidum immobilization (TPI) procedure of Nelson. Nelson and his co-workers¹ observed positive reactions in all of 33 patients with various types of central nervous system (CNS) syphilis. Interestingly enough, of 25 patients classified as latent syphilis, 6 showed TPI antibody in the spinal fluid. Durel and his co-workers² observed only 78% positive TPI reactions in a group of 54 spinal fluids of patients with neurosyphilis. Of 25 patients classified as latent syphilis, 7 were found to have positive TPI tests on the spinal fluid. Zellman and Lutz³ observed a similar sensitivity of 77% in a group of 26 patients with CNS syphilis. Again, 4 of 11 patients with supposed latent syphilis had positive TPI tests on the spinal fluid. These workers conclude that in neurosyphilis the TPI antibody . . . [Full Text PDF of this Article]

Author Affiliations
New York; Los Angeles; New York

From the Department of Dermatology and Syphilology of the New York University Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman) and the Skin and Cancer Unit of the New York University Hospital (Drs. Kostant, Landy, and Kelcec); from the Department of Infectious Diseases, University of California Medical Center, School of Medicine (Dr. Miller).

Footnotes
Submitted for publication March 10, 1959.

Read before the Ninth Annual Symposium on Recent Advances in the Study of Venereal Diseases, Philadelphia, May 12-13, 1958.

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