This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. Influences of the Low Phenylalanine and Tyrosine Diet upon Patients with Collagen Disease

N. NISHIMURA, M.D.; H. OKAMOTO, M.D.; M. YASUI, M.D.; K. MAEDA, M.D.; K. OGURA, M.D.

AMA Arch Derm. 1959;80(4):466-477.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Previously, we^1-3 reported the constant and specific presence of 2,5-dihydroxyphenylpyruvic acid, an imaginary intermediary metabolite of phenylalanine and tyrosine, in urine of diffuse collagen disease patients, and that L-tyrosine dosage unfailingly aggravated both clinical signs and laboratory data of collagen disease. Founded on these facts, low phenylalanine and tyrosine dietary treatment has been performed on 26 diffuse collagen disease patients with good results in both clinical signs and laboratory data.

Commonly, high-protein diet has been recommended for the treatments of collagen disease and also a few specific dietary treatments^4-14 have been known.

Many investigators^15-18 obtained good results in mental deficiency of phenylketonurics on well-defined synthetic diets deficient in phenylalanine.

Armstrong and Tyler and Woolf et al. suggested that the phenylalanine-restricted diet should be initiated at a very early age in order to prevent irreversible damage to the central nervous system.

The . . . [Full Text PDF of this Article]

Author Affiliations
Wakayama, Japan

Department of Dermatology & Urology, Wakayama Medical College.

Footnotes
Submitted for publication Oct. 26, 1958.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?