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Observations on Threshold Reactions

JOHN B. HAEBERLIN, Jr., M.D.; JACK M. FOX, M.D.

AMA Arch Derm. 1959;80(6):690-699.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The importance of primary irritation of the skin in producing an eczematous dermatitis by itself, as well as influencing the engendering of an allergic eczematous contact dermatitis is well documented. The recent literature is replete with articles adding to the fund of observations on mechanisms of pathogenesis of the eczematous sensitization and various aspects of dermatitis and eczema, but relatively few references are found under the heading of primary irritation as such. At present much of this information is found under such topics as contact dermatitis due to specific agents, thermal injuries, industrial dermatitis, and eczemas of various sorts, and it is inseparably linked with studies on allergic reactions in the skin. This is quite understandable since the need for such a term arose from the introduction of the concept of allergy which called for a designation to distinguish allergic from nonallergic forms . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Dermatology, University of Illinois College of Medicine (Drs. Haeberlin and Fox) and The Department of Dermatology, Presbyterian-St. Luke's Hospital (Dr. Haeberlin).

Footnotes
Submitted for publication July 30, 1959.

Read before the 79th Annual Meeting of the American Dermatological Association, Inc., June 1, 1959.

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