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II. Cutaneous Tumors—Introduction and Discussion of Transmissible Reticulum-Cell Tumor

MILTON ORKIN, M.D.; ROBERT M. SCHWARTZMAN, V.M.D., M.P.H., Ph.D.

AMA Arch Derm. 1960;81(3):347-358.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In previous reports we have presented a general introduction to comparative canine and human dermatology¹ and discussed mast cell disease in both species.² In the latter report we noted the following:

1. Cystic rarefaction of the ischium, in one of our canine cases, which coincided closely to some reported cases of bone involvement in human urticaria pigmentosa.³
   
2. That the inability of canine mastocytoma to wheal on physical trauma may be a function of the large number of eosinophils present (their antihistamine content ⁴). Our attempts to correlate the wheal-inhibiting effect of eosinophils in several cases of human urticaria pigmentosa were inconclusive. This thesis shall be tested in a large series of cases.
   
3. That the presence of mast cells in viscera, bone marrow, etc., in mast cell disease (in either species) may not be evidence of metastasis, but may reflect an overgrowth of mast cells present
   

Author Affiliations
Oakland; St. Paul

Formerly trainee, National Cancer Institute and fellow, Division of dermatology, University of Minnesota, Dr. F. W. Lynch, Director; presently Lieutenant U.S.N.R., Oakland Naval Hospital, Oakland (Dr. Orkin); Instructor in veterinary medicine, University of Minnesota; research fellow, Mark L. Morris Memorial Animal Foundation (Dr. Schwartzman).

Footnotes
Submitted for publication June 1, 1959.

Supported in part by a grant, Minnesota Division, American Cancer Society, Inc.

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