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Lesions in the Skin of Chicken

R. H. RIGDON, M.D.

AMA Arch Derm. 1960;81(3):381-387.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been suggested by Liang and Cowdry^1-3 that hair follicles are the primary site of neoplastic response when methylcholanthrene is applied to the skin of the mouse. Other investigators have emphasized the importance of the hair follicle in the development of tumors in the skin.^4,5 Ghadially⁶ observed papillomas and keratoacanthomas arising from the pilosebaceous apparatus in the skin of rabbits treated with 9,10-dimethyl-1,2-benzanthracene.

Much confusion has arisen as to terminology for certain of these carcinogenic-induced tumors in the skin of experimental animals. Ghadially⁶ recently reviewed this problem, and showed the similarity of these experimentally-induced lesions in the rabbit to the keratoacanthoma that occurs spontaneously in man. He pointed out, "The present work leaves little doubt that a large majority of the so-called epitheliomas produced in rabbits by experimental cancer workers since experiments in chemical carcinogenesis commenced were in fact not true cancers but keratoacanthomas." During . . . [Full Text PDF of this Article]

Author Affiliations
Galveston, Texas

Professor of Pathology, University of Texas Medical Branch.

Footnotes
Submitted for publication May 6, 1959.

This investigation was supported by grant from USPH C-1369(C6), National Cancer Institute, Public Health Service.

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