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Survival of Human Skin Transplanted into the Cheek Pouch of the Golden Hamster
BERNARD RESNICK, M.D.;
EUGENE M. FARBER, M.D.;
GEORGE P. FULTON, Ph.D.
AMA Arch Derm. 1960;81(3):394-399.
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Although the technique of heterotransplantation of human tissue into small animals has been used in the field of cancer research for many years,3-5,7 its applicability to research in dermatology has been explored only recently.17
Investigation into the nature of many skin diseases is hampered because such disorders do not occur naturally in experimental animals. It was our thought that the skin from patients with some of the histologically identifiable dermatoses (e.g., psoriasis and lichen planus) might be transplanted into the hamster cheek pouch and still retain its pathological characteristics. If, for instance, psoriatic skin would grow as such, distinctly different from normal skin under like circumstances, then the investigative possibilities would be appreciable.
A corollary objective of this study was to determine the necessity, if any, of cortisone treatment for the survival of heterotransplants of this nature.
Materials and Methods
The cheek pouch of the Golden hamster was
. . . [Full Text PDF of this Article]
Author Affiliations
San Francisco
From the Division of Dermatology, Stanford University School of Medicine.; Sophus Goth Fellow in Dermatology, Stanford University School of Medicine (Dr. Resnick).
Footnotes
Submitted for publication May 19, 1959.
Visiting Professor on leave from Boston University, Department of Biology (Dr. Fulton).
Supported by USPHS Grant No. H-3833 in part and by the Herbert L. Harband Dermopathology Fund in part.
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