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Effect of Chloroquine on Erythematous and Carcinogenic Response to Ultraviolet LightDemonstrated in Experimental Animals
JOHN M. KNOX, M.D.;
A. C. GRIFFIN, Ph.D.;
R. E. HAKIM, Ph.D.
AMA Arch Derm. 1960;81(4):570-576.
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During a lifetime, exposed areas of the body are subject to large amounts of irradiation from sunlight. Unna was the first to call attention to the high incidence of skin cancer among sailors exposed to sunlight,1 and his observation on the relationship between exposure to sunlight and the development of skin cancers has been confirmed by many others. Also, epitheliomas have been produced experimentally by subjecting albino mice, rats, and rabbits to repeated exposures to ultraviolet rays produced by a mercury arc lamp.2-5 The carcinogenic wave lengths of the spectrum have been determined to be between 2,900 and 3,341 A. In experimental animals, the amount of effective midultraviolet radiant energy necessary to initiate changes which culminate with tumor formation is relatively small (63 to 84x107 ergs/sq. cm.).5 To a certain extent, the length of the precancerous period varies inversely with the daily dose of irradiation. Carcinogenesis, once
. . . [Full Text PDF of this Article]
Author Affiliations
Houston, Texas
From the Departments of Dermatology and Biochemistry, Baylor University College of Medicine, Houston, Texas, and the Department of Biochemistry, The University of Texas M. D. Anderson Hospital and Tumor Institute. Supported by grants from the Medical Research Branch, Research and Development Division, Department of the U.S. Army, and the Robert A. Welch Foundation.
Footnotes
Submitted for publication July 13, 1959.
Read before the Section on Dermatology at the 108th Annual Meeting of the American Medical Association, Atlantic City, N.J., June 12, 1959.
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