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LEONARD MELTZER, M.D.

Arch Dermatol. 1960;82(2):264-265.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Continued efforts have been directed toward discovering and developing new and safer local anesthetic agents for minor surgical procedures. Increased awareness of hypersensitivity to paraaminobenzoic acid derivatives¹ and the phenomenon of cross-sensitization of substances seemingly unrelated to them² has further stimulated the search. Compounds such as antihistamines, which are in no way related to PABA, have received some attention. The topical anesthetic value of tripelennamine hydrochloride, mepyramine, and promethazine hydrochloride has been recognized and utilized for some time. In August, 1954, Haranath³ reported that promethazine hydrochloride (Phenergan) resulted in prolonged and effective anesthesia when introduced intradermally or subcutaneously. He did notice some local inflammatory effect.

Stimulated by Haranath's experience, it was decided to use promethazine hydrochloride for local anesthesia in office minor surgery. Thirty-three patients, twenty-four white men and nine white women with no known hypersensitivities, were selected at random. Promethazine hydrochloride in concentration of 25 mg. . . . [Full Text PDF of this Article]

Author Affiliations
Houston, Texas

Assistant Clinical Professor of Dermatology, Baylor University College of Medicine (Dr. Meltzer).

Footnotes
Submitted for publication Oct. 26, 1959.

Phenergan used in this study was supplied by Wyeth Laboratories, Philadelphia.

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