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LORRAINE FRIEDMAN, Ph.D.; VINCENT J. DERBES, M.D.; THEODORE A. TROMOVITCH, M.D.

Arch Dermatol. 1960;82(3):415-418.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1958, attention was focused on griseofulvin, the first orally administered chemotherapeutic agent effective against dermatophyte infections. The clinical trials^1-10 thus far reported leave little doubt as to the curative effect of this antibiotic against tinea capitis, even those cases caused by Microsporum audouini. Little is known, however, concerning the optimal dosage. For example, Blank and Roth¹ treated two cases of M. audouini tinea capitis with daily dosages of 1-2 gm. for approximately four weeks. Sternberg et al.⁸ reported the clinical cures of 18 patients with tinea capitis due to M. audouini in three to nine weeks after any of a wide variety of dosages. Kirk and Ajello³ treated patients with 3 to 17 mg. per pound of body weight daily, some of these for four weeks, others longer. These authors felt that in general they observed better results in those patients who received at least . . . [Full Text PDF of this Article]

Author Affiliations
New Orleans

From the Departments of Microbiology and Medicine (Dermatology), Tulane University School of Medicine.

Footnotes
Submitted for publication Dec. 16, 1959.

A portion of these data were presented by Dr. Derbes at a round-table discussion at the International Symposium on Griseofulvin, Miami, Fla., 1959.

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