This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

RICHARD L. LIPSON, M.D.; EDWARD J. BALDES, Ph.D.

Arch Dermatol. 1960;82(4):517-520.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During a study of photodynamic action in white mice we became aware of the effect of heat on this process. A review of the literature revealed that little work had been done regarding this problem, and available reports provided conflicting results. In an effort to resolve these differences, we decided to study the influence of heat on the photodynamic process in white mice.

Materials and Methods

Photosensitizer.—

The acetic acid-sulfuric acid derivative of hematoporphyrin hydrochloride was used as in previous experiments because of the work of Schwartz, alone⁹ and with others,^10,11 who showed the commercial hematoporphyrin to be a crude mixture of many porphyrins. Solutions containing 10 mg. per milliliter were made up and stored in brown bottles under refrigeration.

Animals.—

White BALB male mice, 6 to 7 weeks old, were used in the experiments.^* The photosensitization, light, temperature, dark box, and animal wheel used in this study . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn.

Fellow in Medicine, Mayo Foundation (Dr. Lipson); Section of Biophysics, Mayo Clinic and Mayo Foundation (Dr. Baldes). The Mayo Foundation Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

Footnotes
Submitted for publication April 8, 1960.

The investigation on which this report is based was supported in part by Cancer Institute Research Fellowship Grant No. CF9880.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?