 |
|
Progressive Fatal Cutaneous Gangrene Associated with Hypogammaglobulinemia
DONALD C. ABELE, M.D.;
RICHARD L. DOBSON, M.D.;
JAMES F. NEWSOME, M.D.;
A. S. LINEBERGER, M.D.
Arch Dermatol. 1960;82(4):565-569.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
In 1952 Bruton1 reported the first known case of agammaglobulinemia. With newer refinements in methods of analysis of serum proteins, a clearer concept of this syndrome has developed.
In brief, the clinical features of agammaglobulinemia or hypogammaglobulinemia are:
- Extreme susceptibility to infection
- Low to absent
 -globulin in the serum
- Immunologic unresponsiveness to antigenic challenge
- Frequent clinical improvement of symptoms with -globulin therapy.
Physical examination usually reveals no abnormalities, although there may be a generalized decrease in lymphoid tissue and lack of regional lymphadenopathy in response to local infection.2
Because of the lack of specificity of signs and symptoms, only a high index of suspicion and the use of appropriate laboratory studies can lead to the correct diagnosis. On routine determination of total serum proteins a globulin of 1 gm. % or less is suggestive of hypogammaglobulinemia. The diagnosis can be confirmed by serum electrophoresis or immunochemical analysis. Other laboratory findings
. . . [Full Text PDF of this Article]
Author Affiliations
Chapel Hill, N.C.
From the Division of Dermatology, Department of Medicine (Donald C. Abele and Richard L. Dobson), Department of Surgery (James F. Newsome), and Department of Pathology (A. S. Lineberger), University of North Carolina School of Medicine.
Footnotes
Submitted for publication Feb. 5, 1960.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
