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J. DONALD IMBRIE, M.D.; LESTER L. BERGERON, M.D.; THOMAS B. FITZPATRICK, M.D., Ph.D.

Arch Dermatol. 1960;82(4):617-620.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Extensive use of methoxsalen in patients with a tendency to easy sunburning and poor tanning resulted in enthusiastic testimonials which claimed increased tanning and decreased burning. A controlled study designed to test the validity of the testimonial evidence did not support it.¹ The double-blind study of Daniels et al. was carried out on 106 patients, most of whom received 10 mg. and a few, 20 mg. of methoxsalen. In this study the patients failed to discriminate between lactose placebos and methoxsalen as to their sunburning and tanning responses. The high incidence of effects attributed to the placebos emphasized the high inherent error of the testimonial data. It was believed that the "use of a higher dose of active drug might have led to a better separation of drug and placebo groups." Previous studies indicated that 20 mg. of methoxsalen is the minimum effective dose for the majority of persons . . . [Full Text PDF of this Article]

Author Affiliations
Portland, Ore.; Boston

Footnotes
Submitted for publication Jan. 25, 1960.

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