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Necrobiosis Lipoidica, a Form Fruste of Diabetes Mellitus

MARVIN F. ENGEL, M.D.; J. GRAHAM SMITH, Jr., M.D.

Arch Dermatol. 1960;82(5):791-797.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The specificity of the vascular lesions of the kidney, retina, and vasa nervosum in diabetes mellitus^{1,2,8-12,20,31} and the relationship of the protein-bound carbohydrate to their pathogenesis have been the subject of much recent research and speculation.^{4,5,13, 14,28} Elevation of the total protein-bound hexose and of the 2-glycoprotein in the serum, together with the presence of mucopolysaccharide in the affected vessels, have been demonstrated repeatedly in the presence of the specific vascular complications of diabetes.^* Similar findings have been reported in patients with necrobiosis lipoidica without diabetes mellitus.⁶ It is the purpose of this paper to clarify the relationship between these diseases and to present immunologic evidence for the presence of an abnormal serum protein or proteins common to both.

One method of separating and identifying complicated mixtures of antigen and antibody is the diffusion-in-gel technique. When employing protein antigens, sharply defined zones of reaction are noted because . . . [Full Text PDF of this Article]

Author Affiliations
Brunswick, Ga.; Durham, N.C.

From the Veterans Administration Hospital, Coral Gables, Fla. and the Department of Dermatology, University of Miami School of Medicine, Miami, Fla.

Present addresses: 2001 Gloucester St., Brunswick (Dr. Engel); Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham (Dr. Smith).

Footnotes
Submitted for publication March 30, 1960.

This study was supported in part by Grant No. A-2586 from the National Institutes of Health.

This study received the Second Award in the 10th Annual Essay contest of the American Dermatological Association, Inc.

This study was carried out during the tenure of a special postdoctoral fellowship of the National Institute of Arthritis and Metabolic Diseases (Dr. Smith).

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