This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Vascular Effects of Parenteral Doses in Atopic Dermatitis

LEALAND L. CLARK, M.D.; ROBERT R. KIERLAND, M.D.; GRACE M. ROTH, Ph.D.

Arch Dermatol. 1960;82(6):957-964.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1953, Lobitz and Campbell¹¹ described a strikingly abnormal cutaneous response in patients with atopic dermatitis. When acetylcholine and its derivative methacholine (acetyl-β-methylcholine; Mecholyl) were injected intradermally, a delayed blanch of the skin was seen at the site of injection. This was in marked contrast to the erythematous wheal that developed in normal persons. The occurrence of this delayed blanch has since been confirmed by many investigators,^4,14,17,19 most of whom have accepted vasoconstriction as the cause of the delayed blanch reaction.^3,12,17

This unique local vascular reaction raised the question of how patients with atopic dermatitis would respond to parenteral administration of acetylcholine and its derivatives. Our study was undertaken in an attempt to answer this question. The methyl derivative of acetylcholine, methacholine, was employed because of its increased resistance to hydrolysis. Its vascular effects are those of the parent substance.^14,21

Procedure

Subjects and Patients.—

Thirty persons . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn.

Fellow in Dermatology, Mayo Foundation (Dr. Clark), Section of Dermatology (Dr. Kierland) and Section of Physiology (Dr. Roth), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

Footnotes
Submitted for publication June 2, 1960.

Abridgment of thesis submitted by Dr. Clark to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Dermatology.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?