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Fluocinolone Acetonide
HARRY M. ROBINSON, JR., M.D.
Arch Dermatol. 1961;83(1):149-151.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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A new synthetic corticoid, fluocinolone acetonide (6 , 9-difluoro 16, 17-isopropylidenedioxy- '-hydrocortisone), has been submitted for study.
This report summarizes the results of double blind studies and the effect of this new drug in the treatment of dermatoses which normally respond to topical steroid therapy.
Procedure
The Drug.—
Fluocinolone acetonide proved to be ineffective on oral administration in the treatment of generalized dermatoses which normally respond to systemic steroid therapy.1 When applied topically in suitable vehicles, the steroid was effective in the treatment of eczematous lesions.1
Preparations Used.—
All preparations used in the double blind studies were received under code label. The 4 creams used contained: (1) no medication as a control, (2) 0.025% fluocinolone acetonide, (3) 0.1% triamcinolone acetonide, and (4) 1.0% hydrocortisone. The fluocinolone acetonide cream and lotion used in the balance of this study contained 0.025% of the active ingredient.
The formulae of the lotion vehicles are:
. . . [Full Text PDF of this Article]
Author Affiliations
BALTIMORE
From the Division of Dermatology, Department of Medicine, University of Maryland School of Medicine.
Footnotes
Submitted for publication June 16, 1960.
The supplies of fluocinolone acetonide used in this study were received from Dr. Harry Rudel of the Syntex Chemical Company, Inc., New York City.
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