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Harold N. Cole, Jr., M.D.; Sam I. Sato, M.D.; Thomas E. Netherton, M.D.

Arch Dermatol. 1961;83(1):159-165.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Letterer-Siwe Disease (Acute Disseminated Histiocytosis X). Presented by DR. A. E. WALKER, DR. J. J. STEWART, and DR. P. J. CRONE.

History.—

A 6-month-old white male infant was first seen at the age of 2 months with a reddish, blistering, seborrheic eruption on the scalp, face, neck, chest, arm folds, palms, the plantar aspect of the feet, and groin. Several nonpainful ulcers of the mouth also were present. The eruption appeared shortly after birth as discrete, firm nodules on the plantar and palmar areas. The eruption gradually spread, but the child gained weight, increased in size, and appeared to be healthy until approximately 3 months of age, when he suddenly became easily irritated, developed anorexia, skin pallor, and a hacking cough. This was followed by the onset of a fever, drainage from the right ear, and a marked enlargement of the right side of the neck.

Physical Examination.—

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Footnotes
Submitted for publication July 18, 1960.

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