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LEONARD C. HARBER, M.D.; ARTHUR B. HYMAN, M.D.; SONIA D. MORRILL, M.D.; RUDOLF L. BAER, M.D.

Arch Dermatol. 1961;83(2):199-203.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical effects of reserpine in 3 patients with urticaria pigmentosa have been described by Baer, Bersani, and Pelzig.¹ Under reserpine therapy they noted a decrease in the tendency of the lesions to urticate in 2 cases after one week and a peculiar "flushing" sensation within 24 hours in the third case. They postulated that perhaps these changes might have been due to degranulation of the basophilic granules in the tissue mast cells. This view was in accord with previous studies by others on the effects of reserpine on enterochromaffin cells in laboratory animals. Degranulation of the enterochromaffin cells after reserpine therapy had been noted by Benditt and Wong² in guinea pigs, and by Marks, Sorgen, and Hayes³ in rats. More recently the effects of reserpine in some cases of urticaria pigmentosa reported by Baer et al. have been confirmed by Dillaha⁴ and by Neill.⁵ . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Dermatology and Syphilology of the New York University Post-Graduate Medical School (Dr. Rudolf L. Baer, Acting Chairman) and the Skin and Cancer Unit of University Hospital.

Footnotes
Submitted for publication Aug. 8, 1960.

This study was aided by a grant from the National Institute of Health (E1361[4]).

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