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An Application of the "pH Signature" Technique to Sections of Skin of Basal- and Squamous-Cell Carcinoma

ALVAN G. FORAKER, M.D.

Arch Dermatol. 1961;83(3):392-401.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Comparisons of microscopic pattern of neoplastic and non-neoplastic cells are of daily practical importance in the diagnosis of tumors and the management of cancer patients. Comparisons of chemical pattern are still largely in the field of research¹ but are an essential step in furthering our understanding of neoplasia.² For some years we³ have been applying new cell techniques developed by histochemists and cytophysicists to the study of human cancer.

One technique of considerable potential is the "pH signature."^4,5 Proteins differ according to the nature and number of their constituent amino acids and conjugated substances.⁶ Proteins are amphoteric. They contain at the same time both basic and acidic groups, which, by their dissociation, give rise to positive and negative charges on the protein molecule. The ability of proteins to take up acid or basic dye according to the pH of the solution is an expression of . . . [Full Text PDF of this Article]

Author Affiliations
JACKSONVILLE, FLA.

From the Research Laboratory, Baptist Memorial Hospital.

Footnotes
Submitted for publication Sept. 30, 1960.

This investigation was supported by research grants from the National Cancer Institute, National Institutes of Health, Public Health Service (C-2899, C-2719), and the Damon Runyon Memorial Fund (DRG-352, DRG-478).

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