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The Affinity of Hydroxystilbamidine for Psoriatic Lesions
DAPHNE ANDERSON ROE, M.D.
Arch Dermatol. 1961;83(4):584-586.
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Recent clinical trials with 2-hydroxystilbamidine isethionate in psoriasis (11 cases) showed that the drug becomes localized in the psoriatic areas, both on the glabrous skin and in the nails. This localization of the drug was revealed by examination of the patients under Wood's light. With this method an intense yellow fluorescence of affected areas could be seen. Gentle scraping of the psoriatic lesions showed that this fluorescence was mainly limited to the scale (Fig. 1). In the nails the fluorescence was apparent in the dystrophic parts only, especially in the abnormal adherent hyponychium.
Examination of the skin, scale, and nail sections by fluorescence microscopy revealed that hydroxystilbamidine was concentrated in the cytoplasm of the parakeratotic cells. The yellowish-white fluorescence, denoting the presence of the drug within these cells, had a diffuse cytoplasmic distribution, but, in addition, there were groups of brightly fluorescent yellow granules in some areas. Slight cytoplasmic and
. . . [Full Text PDF of this Article]
Author Affiliations
WILMINGTON, DEL.
From the Department of Pathology, Memorial Hospital.
Footnotes
Submitted for publication Sept. 29, 1960.
This investigation was supported by research Grant No. RG-6749 (A) from the National Institutes of Health, U.S. Public Health Service, and also by a Grant from the Permanent Science Fund of the American Academy of Arts and Sciences.
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