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Urinary Excretion of General Intermediary Metabolites of Tyrosine in Patients with Collagen Disease and Liver Disease

NAGAO NISHIMURA; KOZO MAEDA; MASATAKA YASUI; HISASHI OKAMOTO; MASAHIRO MATSUNAKA; HAJIMU TOSHINA

Arch Dermatol. 1961;83(4):644-652.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The specific and constant presence of 2,5-dihydroxyphenylpyruvic acid (2,5-DHPPA), an imaginary intermediary metabolite of phenylalanine and tyrosine in the urine of collagen disease patients, has been spotted by us1 on the one-dimensional ascending paper chromatogram, although the existence of the substance of 2,5-DHPPA is itself thought deniable by La Du et al.,^2,4 and the specificity of the spot to collagen disease is negated by Tye et al.,⁵ who consider the spot due to salicylic acid derivatives. The spot that has been determined by us as 2,5-DHPPA or its lactone⁶ on paper chromatogram still lacks biochemical evidences to confirm the absolute identification.

Aside from the disputes concerning the substance of 2,5-DHPPA, the facts that the clinical and laboratory status of collagen disease are undoubtedly alleviated by a low phenylalanine and tyrosine diet,⁷ and aggravated by the administration of 1-tyrosine in their active stage, have been established . . . [Full Text PDF of this Article]

Author Affiliations
WAKAYAMA, JAPAN

From the Department of Dermatology and Urology, Wakayama Medical College Hospital (Professor Nagao Nishimura, Director).

Footnotes
Submitted for publication May 31, 1960.

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