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DANIEL E. HACKBARTH, M.D.; LEONARD S. MARKSON, M.D.

Arch Dermatol. 1961;83(4):659.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hyperhidrosis of the feet is a common problem, especially in warm climates and during summer months. It is embarrassing and uncomfortable, and can have fairly serious consequences such as maceration of the skin and exacerbation of intercurrent dermatoses. Hyperhidrosis significantly retards healing of dermatophytosis.

Formaldehyde solution, aluminum chloride, potassium permanganate, and ferric chloride are used topically with some success; however, sensitization (as with formaldehyde) or staining (as with ferric chloride and potassium permanganate) are disadvantages. Anticholinergic agents, administered orally, exert a marked anhidrotic effect through parasympathetic inhibition. Oral administration of diphemanil methylsulfate (Prantal), a quaternary ammonium compound, provides satisfactory relief of hyperhidrosis,^1,2 but xerostomia and other undesired effects of parasympathetic inhibition occur in a significant number of patients. The drug is available for topical use as a 2% cream, which is effective against hyperhidrosis³ and against dermatoses in which moisture is an exacerbating factor.^4,5,6 Recently, diphemanil methylsulfate . . . [Full Text PDF of this Article]

Author Affiliations
MILWAUKEE

Footnotes
Received for publication Aug. 30, 1960.

Diphemanil methylsulfate (Prantal) dusting powder (CMR-822) was provided for this clinical trial by G. Kenneth Hawkins, M.D., Department of Clinical Investigation, Medical Research Division, Schering Corporation, Bloomfield, N.J. Each gram contains 20 mg. diphemanil methylsulfate and inert powders. The powder at present is not commercially available.

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