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A New Topical Corticosteroid

HOWARD R. GRAY, M.D.; ROBERT L. WOLF, M.D.; RONALD H. DONEFF, M.D.

Arch Dermatol. 1961;84(1):18-21.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Flurandrenolone^* is a new corticosteroid which has a chemical formula of 6-fluoro-16-hydroxyhydrocortisone-16,17-acetonide. This new steroid is distinguished from hydrocortisone by the presence of 2 activityenhancing groupings, a 6-fluorine and a 16-OH. The structural formula follows:

Substitution of an alpha-fluorine atom for hydrogen at the sixth position and a hydroxyl group at the 16 position, as well as the acetonide function linkage at both the 16- and 17-hydroxyl groups, are new substituents designed to impart maximum potency as an anti-inflammatory agent. At the same time, the salt-retaining property of the parent compound is decreased.¹

Pharmacological animal data by Kraay confirmed this increased potency and decreased sodium retention.² Flurandrenolone was assayed using the standard methods of thymus involution and inhibition of granuloma formation around a cellulose pellet in adrenalectomized rats. On the basis of thymus involution, flurandrenolone appeared to have about 10 times the oral potency of prednisolone and from . . . [Full Text PDF of this Article]

Author Affiliations
INDIANAPOLIS

From the Department of Dermato-Syphilology, Marion County General Hospital (Chairman, Boynton H. Booth, M.D.).

Footnotes
Submitted for publication Feb. 27, 1961.

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