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PHILIP C. ANDERSON, M.D.

Arch Dermatol. 1961;84(1):99-102.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1959 Wissinger and I published a report on the incidence of cutaneous eruptions due to sulfamethoxypyridazine.¹ Simply, the method involved giving a standard dose of the drug to a large group of patients and counting the number of allergic reactions. Statisticians were consulted in regard to the design of the study. During the design phase, and especially while carrying out the study, it became evident that most of the uncertainty and probable error in the experiment were not problems of statistics. The difficulties were due to the vagueness and incompleteness of basic medical knowledge and to limitations in selection, supervision, and observation of patients in medical studies.

Simple counting methods involve fewer problems than do methods requiring measurement or judgment. This paper is concerned with the analysis of the simple counting study. An ideal mathematical model will be described and contrasted with the practical clinical study. I wish . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

Department of Dermatology, University Hospital.

Footnotes
Submitted for publication Jan. 24, 1961.

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