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Preliminary Identification

H. Y. YEE, M.S.; D. S. McCANN, Ph.D.; M. K. KEECH, M.D.; C. W. DENKO, M.D., Ph.D.; A. J. BOYLE, M.D., Ph.D.

Arch Dermatol. 1961;84(2):293-301.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The immediate precursor of homogentisic acid has been the subject of speculation since Neubauer first postulated the metabolic pathways from phenylalanine and tyrosine to the citric acid cycle.^1-10 In fact not all features of this theoretical flowsheet have as yet been substantiated by experimental evidence. The occurrence of 2,5 dihydroxyphenylpyruvic acid (2,5 DHPPA) in human urine has remained largely hypothetical. In 1958, Nishimura and coworkers^11-12 demonstrated for the first time the presence of 2,5 DHPPA in the urine of patients with connective tissue diseases. However, the method used by them for detecting the 2,5 DHPPA was qualitative and subject to question with respect to the amount and identity of the material found. In 1959 Tye et al.,¹³ using ultraviolet spectrophotometry and paper chromatography, reported that 2,5 DHPPA was not detected by their methods. This paper is concerned with presenting evidence which supports the view that 2,5 DHPPA . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT; COLUMBUS, OHIO; DETROIT

From Wayne State University, Departments of Chemistry and Medicine, and The Ohio State University, Department of Medicine.

Fellow of the Michigan Heart Association (Mr. Yee); Senior Investigator of the Arthritis and Rheumatism Foundation (Dr. Denko).

Footnotes
Submitted for publication Jan. 23, 1961.

This work was supported in part by a Grant-in-Aid from the National Institutes of Health.

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