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A Clinical Study of 727 Cases

DENNY L. TUFFANELLI, M.D.; R. K. WINKELMANN, M.D.

Arch Dermatol. 1961;84(3):359-371.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Scleroderma was described centuries ago, and yet today the physician has little to offer other than the diagnosis. The etiology remains obscure; the course is unpredictable, and therapy is of little benefit. The term "scleroderma" is limited, for literally it means merely "hard skin." Under this label are included disease processes varying from the sclerosis of a bit of skin to overwhelming systemic reactions terminating in rapid death. While innumerable case reports and reviews of scleroderma have appeared in the literature, we believed that a longterm clinical study, unique in the extremely large number of patients observed, would add to our knowledge of a poorly understood entity.

Classification

The classification of scleroderma used in the Section of Dermatology at the Mayo Clinic is as follows:

1. Localized
   
   1. Morphea
      
   2. Generalized morphea
      
   3. Linear scleroderma
      
      1. En coup de sabre
         
      2. Hemiatrophy
         
      
      
   
   
2. Systemic
   
   1. Acrosclerosis
      
   2. Diffuse scleroderma
      
   
   

Author Affiliations
ROCHESTER, MINN.

Fellow in Dermatology, Mayo Foundation (Dr. Tuffanelli); Section of Dermatology, Mayo Clinic and Mayo Foundation (Dr. Winkelmann).

Footnotes
Submitted for publication June 14, 1961.

Abridgment of thesis submitted by Dr. Tuffanelli to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Dermatology.

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